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Insulin-like growth factor 1 NS has potent antidiabetic activity, as reflected by the up-regulation of several essential genes, such as insulin-like growth factor-1 and IGF-1

Funding This work was supposed by the Yiwu 133 Innovative Talent Project (to YP Wu), and Zhejiang Provincial Department of Education Project (Y202353450, to LL Li)

Additionally, within 5 years of disease diagnosis, almost all patients with T1D lose their ability to generate an adequate glucagon response to hypoglycemia [123]

The self-consistent calculations apply a convergence energy threshold of 10 5 eV, and the force convergency was set to 0.05 eV/